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Recent Articles

Endocardial Approach for Substrate Ablation in Brugada Syndrome: Epicardial, Endocardial or Transmural Substrate?

Background: Radiofrequency ablation (RFA) in Brugada syndrome (BrS) has been performed both endocardially and epicardially. The substrate in BrS is thus unclear. Objectives: To investigate the functional endocardial substrate and its correlation with clinical, electrophysiological and ECG findings in order to guide an endocardial ablation. Methods: Thirteen patients (38.7±12.3 years old) with spontaneous type 1 ECG BrS pattern, inducible VF with programmed ventricular stimulation (PVS) and syncope without prodromes were enrolled. Before to endocardial mapping the patients underwent flecainide testing with the purpose of measuring the greatest ST-segment elevation for to be correlated with the size and location of substrate in the electro-anatomic map

Selected Compounds Modulate Various Inflammatory Biomarkers in Lipopolysaccharide-Induced Macrophages of PPAR-α Knockout Mice

Inflammation has been implicated in cancer, diabetes and cardiovascular disease. We have recently screened several compounds that modulate inflammatory biomarkers (TNF-α, IL-1β, IL-6, and nitric oxide) in response to a variety of stimuli. Our hypothesis is that compounds with those anti-inflammatory properties will be useful for treatment of diabetes, cardiovascular disease, and other diseases based on inflammation.

An Investigation into the Physiological and Psychological Impact of Supine and Side Lying Physical Restraint Techniques

This research investigated the physiological and psychological impact of supine and side lying physical restraint (PR) positions which have been suggested as safer alternatives to prone restraint positions. Twenty adults participated. From baseline Forced Vital Capacity (FVC) reduced by 10.4%, 10.4% and 14.6%, and FEV1 reduced by 7%, 7%, and 12% for supine arms low (SPR-AL), supine arms high (SPR-AH), and Side Lying restraint (SLR) respectively. SLR imposed the greatest Thoracic Weight bearing Pressure (TWP) at 116.1 (±17.5) mmHg, which was ~17% more than SPR-AH, and ~23% more than SPR-AL. HR was unaffected.